Vincent van Unen Research Group

Selected Publications

• A Human Autoimmune Organoid Model Reveals IL-7 Function in Coeliac Disease
  Santos AJM, van Unen V, Lin Z, Chirieleison SM, Ha N, Batish A, Chan JE, Cedano J, Zhang E, Mu Q, Guh-Siesel A, Tomaske M, Colburg D, Varma S, Choi SS, Christophersen A, Baghdasaryan A, Yost KE, Karlsson K, Ha A, Li J, Dai H, Sellers ZM, Chang HY, Dunn JCY, Zhang BM, Mellins ED, Sollid LM, Fernandez-Becker NG, Davis MM, Kuo CJ — Nature, 2024
• Immune Subset-Committed Proliferating Cells Populate the Human Foetal Intestine Throughout the Second Trimester of Gestation
  Guo N, Li N, Jia L, Jiang Q, Schreurs M, van Unen V, de Sousa Lopes SMC, Vloemans AA, Eggermont J, Lelieveldt B, Staal FJT, de Miranda N, Pascutti MF, Koning F — Nature Communications, 2023
• Identification of a Disease-Associated Network of Intestinal Immune Cells in Treatment-Naive Inflammatory Bowel Disease
  van Unen V, Ouboter LF, Li N, Schreurs M, Abdelaal T, Kooy-Winkelaar Y, Beyrend G, Hollt T, Maljaars PWJ, Mearin ML, Mahfouz A, Witte AMC, Clemens CHM, Abraham S, Escher JC, Lelieveldt BPF, Pascutti MF, van der Meulen-de Jong AE, Koning F — Frontiers in Immunology, 2022
• KIR+CD8+ T Cells Suppress Pathogenic T Cells and Are Active in Autoimmune Diseases and COVID-19
  Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC, Saligrama N, Davis MM — Science, 2022
• Systems Analysis and Controlled Malaria Infection in Europeans and Africans Elucidate Naturally Acquired Immunity
  de Jong SE, van Unen V, Manurung MD, Stam KA, Goeman JJ, Jochems SP, Hollt T, Pezzotti N, Mouwenda YD, Betouke Ongwe ME, Lorenz FR, Kruize YCM, Azimi S, Konig MH, Vilanova A, Eisemann E, Lelieveldt BPF, Roestenberg M, Sim BKL, Reinders MJT, Fendel R, Hoffman SL, Kremsner PG, Koning F, Mordmuller B, Lell B, Yazdanbakhsh M — Nature Immunology, 2021
• ImaCytE: Visual Exploration of Cellular Micro-Environments for Imaging Mass Cytometry Data
  Somarakis A, Van Unen V, Koning F, Lelieveldt B, Hollt T — IEEE Transactions on Visualization and Computer Graphics, 2021
• Progenitor Identification and SARS-CoV-2 Infection in Human Distal Lung Organoids
  Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la OS, Flynn RA, Margalef-Catala M, Santos AJM, Ju J, Batish A, Usui T, Zheng GXY, Edwards CE, Wagar LE, Luca V, Anchang B, Nagendran M, Nguyen K, Hart DJ, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Harbury PB, Glenn JS, Garcia KC, Davis MM, Baric RS, Sabatti C, Amieva MR, Blish CA, Desai TJ, Kuo CJ — Nature, 2020
• A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue
  Guo N, van Unen V, Ijsselsteijn ME, Ouboter LF, van der Meulen AE, Chuva de Sousa Lopes SM, de Miranda NFCC, Koning F, Li N — Frontiers in Immunology, 2020
• Memory CD4+ T Cells Are Generated in the Human Fetal Intestine
  Li N, van Unen V, Abdelaal T, Guo N, Kasatskaya SA, Ladell K, McLaren JE, Egorov ES, Izraelson M, Chuva de Sousa Lopes SM, Hollt T, Britanova OV, Eggermont J, de Miranda N, Chudakov DM, Price DA, Lelieveldt BPF, Koning F — Nature Immunology, 2019
• Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease
  Mayassi T, Ladell K, Gudjonson H, McLaren JE, Shaw DG, Tran MT, Rokicka JJ, Lawrence I, Grenier JC, van Unen V, Ciszewski C, Dimaano M, Sayegh HE, Kumar V, Wijmenga C, Green PHR, Gokhale R, Jericho H, Semrad CE, Guandalini S, Dinner AR, Kupfer SS, Reid HH, Barreiro LB, Rossjohn J, Price DA, Jabri B — Cell, 2018
• Mass Cytometry Reveals Innate Lymphoid Cell Differentiation Pathways in the Human Fetal Intestine
  Li N, van Unen V, Hollt T, Thompson A, van Bergen J, Pezzotti N, Eisemann E, Vilanova A, Chuva de Sousa Lopes SM, Lelieveldt BPF, Koning F — Journal of Experimental Medicine, 2018
• Visual Analysis of Mass Cytometry Data by Hierarchical Stochastic Neighbor Embedding Reveals Rare Cell Types
  van Unen V, Hollt T, Pezzotti N, Li N, Reinders MJT, Eisemann E, Koning F, Vilanova A, Lelieveldt BPF — Nature Communications, 2017
• Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets
  van Unen V, Li N, Molendijk I, Temurhan M, Hollt T, van der Meulen-de Jong AE, Verspaget HW, Mearin ML, Mulder CJ, van Bergen J, Lelieveldt BP, Koning F — Immunity, 2016