Vincent van Unen Research Group

We are excited to share highlights from our recent Annual Science Retreat, hosted in the inspiring setting of the Naturalis Museum in Leiden.

Surrounded by magnificent dinosaur skeletons and the wonders of natural history, our team engaged in great discussions on the latest discoveries and breakthroughs in immunology.

The unique atmosphere of Naturalis sparked fresh ideas and exciting conversations about the future of our field.

Together, we explored new opportunities to advance research, inspired by the incredible blend of science and history all around us, setting the stage for another year of groundbreaking work!

We are pleased to share our latest research, just published in Nature

Our team at Stanford Medicine has developed a novel human autoimmune organoid capable of replicating celiac disease in vitro.

This ALI organoid system preserves the epithelium, native mesenchyme, and tissue-resident immune cells as a cohesive unit.

Through this model, we discovered an unexpected role for the cytokine interleukin-7 in driving pathology within the intestine.

This human celiac model successfully recapitulates gluten-dependent pathology and offers a new platform for investigating the mechanisms of autoimmune diseases.

This work also establishes a proof of principle for using organoid systems to model autoimmunity.

Big Kudos to the team, especially Antonio Santos and Calvin kuo!

Exciting news from the lab! Today, we received a shipment of brand new equipment that will facilitate our research capabilities.

Among the new arrivals are high-precision pipettes, designed to enhance the accuracy and efficiency of our experiments. Our team is eager to start using these tools to push the boundaries of scientific discovery.

Stay tuned for updates on our research made possible by our latest technological advancements!